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A facile synthesis of Sulfonylureas via water assisted preparation of Carbamates

Abstract

A novel and simple approach to the synthesis of Sulfonylureas has been reported. It involved the reaction of various amines with diphenyl carbonate to yield the corresponding carbamates, which subsequetly reacted with different sulphonamides to produce different sulfonylureas in excellent yields. The first reaction of diphenyl carbonate with amines was carried out in aqueous:organic (H2O:THF, 90:10) medium at room temperature to produce carbamates that paved a straightforward route to sulfonylureas after reaction with sulfonamides. Above process avoided traditional multistep protocols and use of hazardous, irritant, toxic and moisture sensitive reagents such as phosgene, isocyanates and/or chloroformates.

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Publication details

The article was received on 07 Apr 2017, accepted on 16 May 2017 and first published on 16 May 2017


Article type: Paper
DOI: 10.1039/C7OB00872D
Citation: Org. Biomol. Chem., 2017, Accepted Manuscript
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    A facile synthesis of Sulfonylureas via water assisted preparation of Carbamates

    D. K. Tanwar, A. Ratan and M. S. gill, Org. Biomol. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7OB00872D

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