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Camphyl-based α-Diimine Palladium Complexes: Highly Efficient Precatalysts for Direct Arylation of Thiazoles in Open-Air

Abstract

Based on the strategy in development of phosphine-free palladium-catalyzed direct C-H arylation, a series of camphyl-based α-diimine palladium complexes bearing bulky steric were synthesized and characterized. The palladium complexes were applied for the cross-coupling of thiazole derivitives with aryl bromides. The effect of the bulky steric on N-aryl moiety as well as reaction conditions was screened. Under the optimal protocols, a wide range of aryl bromides can smoothly coupled with thiazoles in good to excellent yields in the presence of low palladium loading of 0.2 mol% under open-air condition.

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Publication details

The article was received on 06 Apr 2017, accepted on 19 Jun 2017 and first published on 19 Jun 2017


Article type: Paper
DOI: 10.1039/C7OB00856B
Citation: Org. Biomol. Chem., 2017, Accepted Manuscript
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    Camphyl-based α-Diimine Palladium Complexes: Highly Efficient Precatalysts for Direct Arylation of Thiazoles in Open-Air

    F. Chen, D. Lu, L. Hu, J. Huang and F. Liu, Org. Biomol. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7OB00856B

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