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Issue 19, 2017
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Alcohol-mediated direct dithioacetalization of alkynes with 2-chloro-1,3-dithiane for the synthesis of Markovnikov dithianes

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Abstract

An alcohol-mediated dithioacetalization process that gains direct access to the corresponding Markovnikov-selective 1,3-dithianes using unactivated alkynes and nonthiolic/odorless 2-chloro-1,3-dithiane in a highly efficient manner has been developed. This methodology has the advantage of having mild reaction conditions, and the dithioacetalization process gives good to excellent yields with high Markovnikov-selectivity.

Graphical abstract: Alcohol-mediated direct dithioacetalization of alkynes with 2-chloro-1,3-dithiane for the synthesis of Markovnikov dithianes

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Publication details

The article was received on 30 Mar 2017, accepted on 17 Apr 2017 and first published on 19 Apr 2017


Article type: Communication
DOI: 10.1039/C7OB00795G
Citation: Org. Biomol. Chem., 2017,15, 4068-4071
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    Alcohol-mediated direct dithioacetalization of alkynes with 2-chloro-1,3-dithiane for the synthesis of Markovnikov dithianes

    T. Liu, L. Tian, J. Lai, D. Min, M. Qu and S. Tang, Org. Biomol. Chem., 2017, 15, 4068
    DOI: 10.1039/C7OB00795G

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