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Synthesis of cyclooxygenase metabolites of 8,9-epoxyeicosatrienoic acid (EET): 11- and 15-hydroxy 8,9-EETs

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Abstract

COX metabolites of 8,9-EET, previously observed as potent mitogenic lipid mediators, were synthesized for the first time by using two synthetic approaches. These synthetic materials allow for structural confirmation of COX metabolites of 8,9-EET and further study of their biological roles.

Graphical abstract: Synthesis of cyclooxygenase metabolites of 8,9-epoxyeicosatrienoic acid (EET): 11- and 15-hydroxy 8,9-EETs

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Publication details

The article was received on 29 Mar 2017, accepted on 19 Apr 2017 and first published on 25 Apr 2017


Article type: Paper
DOI: 10.1039/C7OB00789B
Citation: Org. Biomol. Chem., 2017, Advance Article
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    Synthesis of cyclooxygenase metabolites of 8,9-epoxyeicosatrienoic acid (EET): 11- and 15-hydroxy 8,9-EETs

    B. Barnych, A. A. Rand, T. Cajka, K. S. S. Lee and B. D. Hammock, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB00789B

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