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Visible-Light-Induced and Iron-Catalyzed Methylation of N-arylacrylamides with Dimethyl Sulphoxide:A Convenient Access to 3-Ethyl-3-Methyl Oxindoles

Abstract

A visible-light-induced and iron-catalyzed methylation of arylacrylamides by dimethyl sulfoxide (DMSO) is achieved, leading to 3-ethyl-3-methyl indolin-2-ones in high yields. This reaction tolerates a series of functional groups, such as methoxy, trifluoromethyl, cyano, nitro, acetyl and ethyloxy carbonyl groups. The visible-light promoted radical methylation and arylation of the alkenyl group are involved in this reaction.

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Publication details

The article was received on 29 Mar 2017, accepted on 20 Apr 2017 and first published on 20 Apr 2017


Article type: Paper
DOI: 10.1039/C7OB00779E
Citation: Org. Biomol. Chem., 2017, Accepted Manuscript
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    Visible-Light-Induced and Iron-Catalyzed Methylation of N-arylacrylamides with Dimethyl Sulphoxide:A Convenient Access to 3-Ethyl-3-Methyl Oxindoles

    Z. Xie, P. Li, Y. Hu, N. Xu and L. Wang, Org. Biomol. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7OB00779E

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