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The dearomative annulation between N-2-pyridylamidine and CO2 toward pyrido[1,2-a]-1,3,5-triazin-4-ones

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Abstract

A base-promoted dearomative annulation between N-2-pyridylamidine and an atmospheric pressure of CO2 was developed, affording a series of pyrido[1,2-a]-1,3,5-triazin-4-ones in moderate to excellent yields. CO2 served as a carbonyl source, releasing H2O as a solely clean byproduct. Moreover, no dehydrating reagent and transition-metal catalyst were required in this procedure. Thus, it represents a green, sustainable and straightforward pathway to access such frameworks.

Graphical abstract: The dearomative annulation between N-2-pyridylamidine and CO2 toward pyrido[1,2-a]-1,3,5-triazin-4-ones

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Publication details

The article was received on 29 Mar 2017, accepted on 19 Apr 2017 and first published on 19 Apr 2017


Article type: Communication
DOI: 10.1039/C7OB00777A
Citation: Org. Biomol. Chem., 2017, Advance Article
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    The dearomative annulation between N-2-pyridylamidine and CO2 toward pyrido[1,2-a]-1,3,5-triazin-4-ones

    M. Xia, W. Hu, S. Sun, J. Yu and J. Cheng, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB00777A

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