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Issue 20, 2017
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Copper-catalyzed oxidative decarboxylative coupling of α-keto acids and sulfoximines

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Abstract

A copper-catalyzed oxidative decarboxylative coupling of α-keto acids with NH-sulfoximines has been developed. With CuBr as the catalyst and K2S2O8 as the oxidant, this reaction enables the formation of a C–N bond and gives N-aroylsulfoximine products in moderate to excellent yields. The reaction mechanism is likely to involve the generation of a reactive aroyl radical intermediate.

Graphical abstract: Copper-catalyzed oxidative decarboxylative coupling of α-keto acids and sulfoximines

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Publication details

The article was received on 29 Mar 2017, accepted on 25 Apr 2017 and first published on 26 Apr 2017


Article type: Paper
DOI: 10.1039/C7OB00776K
Citation: Org. Biomol. Chem., 2017,15, 4320-4327
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    Copper-catalyzed oxidative decarboxylative coupling of α-keto acids and sulfoximines

    C. Pimpasri, L. Sumunnee and S. Yotphan, Org. Biomol. Chem., 2017, 15, 4320
    DOI: 10.1039/C7OB00776K

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