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Multicomponent reaction through cooperative trio catalysis incorporating enamine, Brønsted acid and metal Lewis acid catalysis: a concise route to access chromans

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Abstract

An atom-economical multicomponent cascade reaction of salicylaldehydes, cyclohexanones and arylamines has been developed for the synthesis of three-ring fused chromans. This reaction was achieved through cooperative enamine–metal Lewis acid assisted Brønsted acid catalysis, furnishing the products in excellent yields with good diastereoselectivity.

Graphical abstract: Multicomponent reaction through cooperative trio catalysis incorporating enamine, Brønsted acid and metal Lewis acid catalysis: a concise route to access chromans

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Publication details

The article was received on 27 Mar 2017, accepted on 07 Apr 2017 and first published on 07 Apr 2017


Article type: Communication
DOI: 10.1039/C7OB00753A
Citation: Org. Biomol. Chem., 2017, Advance Article
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    Multicomponent reaction through cooperative trio catalysis incorporating enamine, Brønsted acid and metal Lewis acid catalysis: a concise route to access chromans

    C. V. Karunaratne, R. G. Sarkisian, J. Reeves, Y. Deng, K. A. Wheeler and H. Wang, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB00753A

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