Jump to main content
Jump to site search

Issue 20, 2017
Previous Article Next Article

Natural product driven diversity via skeletal remodeling of caryophyllene β-lactam

Author affiliations

Abstract

(−)-β-Caryophyllene was decorated with a privileged β-lactam motif and subsequently converted into highly diverse scaffolds via remodeling of the ring system. The structures were defined by spectroscopic data, X-ray diffraction analysis, and experimental and calculated ECD data. Compound 19 displayed the most potent activity against the rice blast fungus, while 6 had a more potent α-glucosidase inhibition than the drug acarbose. These findings demonstrate a concise protocol to exploit natural product-driven diversity.

Graphical abstract: Natural product driven diversity via skeletal remodeling of caryophyllene β-lactam

Back to tab navigation

Supplementary files

Publication details

The article was received on 25 Mar 2017, accepted on 02 May 2017 and first published on 02 May 2017


Article type: Paper
DOI: 10.1039/C7OB00741H
Citation: Org. Biomol. Chem., 2017,15, 4456-4463
  •   Request permissions

    Natural product driven diversity via skeletal remodeling of caryophyllene β-lactam

    Q. Zhang, H. Tang, M. Chen, J. Yu, H. Li and J. Gao, Org. Biomol. Chem., 2017, 15, 4456
    DOI: 10.1039/C7OB00741H

Search articles by author

Spotlight

Advertisements