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Development of 19F-NMR chemical shift detection of DNA B–Z equilibrium using 19F-NMR

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Abstract

Various DNA conformational changes are in correlation with biological events. In particular, DNA B–Z equilibrium showed a high correlation with translation and transcription. In this study, we developed a DNA probe containing 5-trifluoromethylcytidine or 5-trifluoromethylthymidine to detect DNA B–Z equilibrium using 19F-NMR. Its probe enabled the quantitative detection of B-, Z-, and ss-DNA based on 19F-NMR chemical shift change.

Graphical abstract: Development of 19F-NMR chemical shift detection of DNA B–Z equilibrium using 19F-NMR

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Publication details

The article was received on 22 Mar 2017, accepted on 20 Apr 2017 and first published on 20 Apr 2017


Article type: Communication
DOI: 10.1039/C7OB00706J
Citation: Org. Biomol. Chem., 2017, Advance Article
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    Development of 19F-NMR chemical shift detection of DNA B–Z equilibrium using 19F-NMR

    S. Nakamura, H. Yang, C. Hirata, F. Kersaudy and K. Fujimoto, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB00706J

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