Construction of protein assemblies by host-guest interactions with cucurbiturils
Protein assemblies are inspiring biomaterials for biomedicine and bioanalysis. Design of protein assemblies with maintained activities is especially important for applications. To address this challenge, cucurbiturils (CB[n]s) that are a family of water-soluble host molecules have been developed which have high affinity toward small peptide motifs, organic cations and amines. CB[n]s have been successfully applied for construction of protein assemblies from 1D to 3D. These protein assemblies possess unique structural, stimuli-responsive and bioactive properties, hopeful for biomedical application. Herein, we reviewed the progress in the design of 3D protein biomaterials based on supramolecular complexations of CB[n]s and present the perspectives in future design of high ordered biomaterials for biomedical applications.