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Issue 20, 2017
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Construction of protein assemblies by host–guest interactions with cucurbiturils

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Abstract

Protein assemblies are extremely interesting in chemistry and supramolecular chemistry. How to design protein assemblies with dimensional structures is important for applications. To address this challenge, cucurbituril (CB[n]s)-based strategies have been explored owing to their high affinity toward small peptide motifs, organic cations and amines. By incorporation of a small molecule guest and a peptide motif guest into N-terminals of oligomeric proteins, CB[n]s could recognize and bind to the N-terminal guests, leading to dimensional protein assemblies. The dimensional protein assemblies possess structural, stimuli-responsive and bioactive properties with great potential for in vivo applications. Herein, we reviewed the progress in the design of dimensional protein assemblies based on supramolecular interactions of CB[n]s and present the perspectives in the design of high-ordered biomaterials for biomedical applications.

Graphical abstract: Construction of protein assemblies by host–guest interactions with cucurbiturils

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Publication details

The article was received on 21 Mar 2017, accepted on 18 Apr 2017 and first published on 18 Apr 2017


Article type: Review Article
DOI: 10.1039/C7OB00686A
Citation: Org. Biomol. Chem., 2017,15, 4272-4281
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    Construction of protein assemblies by host–guest interactions with cucurbiturils

    C. Hou, Z. Huang, Y. Fang and J. Liu, Org. Biomol. Chem., 2017, 15, 4272
    DOI: 10.1039/C7OB00686A

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