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Asymmetric conjugate additions of 2-substituted benzofuran-3(2H)-ones to α, β-unsaturated ketones catalyzed by chiral copper complexes

Abstract

A highly enantioselective conjugate addition of 2-substituted benzofuran-3(2H)-ones with α, β-unsaturated ketones promoted by chiral copper complexes has been developed, affording the Michael addition products with quaternary stereocenters in good to high yields (up to 95% yield) with excellent enantioselectivties (up to 99% ee). The chiral Michael adducts could be readily converted to the polycyclic benzofuran-type framework via Robinson annulation.

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Publication details

The article was received on 20 Mar 2017, accepted on 18 Apr 2017 and first published on 18 Apr 2017


Article type: Paper
DOI: 10.1039/C7OB00677B
Citation: Org. Biomol. Chem., 2017, Accepted Manuscript
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    Asymmetric conjugate additions of 2-substituted benzofuran-3(2H)-ones to α, β-unsaturated ketones catalyzed by chiral copper complexes

    H. Wang, Y. Wang, C. Zhang, Y. Jiang, M. Chu, Z. Li, X. Du and D. Xu, Org. Biomol. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7OB00677B

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