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Synthesis of disulfides tethered pyrroles from β-ketothioamides via bicyclization/ring-opening/oxidative coupling reaction

Abstract

A DABCO-promoted three-component reaction of β-ketothioamides (KTAs), arylglyoxals and 2-cyanoacetates to access disulfides tethered pyrroles by air as oxidant has been disclosed. Importantly, this protocol involves a tandem sequence that includes Knoevenagel condensation, Michael addition, N-cyclization, O-cyclization, ring-opening and oxidative coupling.

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Publication details

The article was received on 17 Mar 2017, accepted on 16 Jun 2017 and first published on 16 Jun 2017


Article type: Paper
DOI: 10.1039/C7OB00655A
Citation: Org. Biomol. Chem., 2017, Accepted Manuscript
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    Synthesis of disulfides tethered pyrroles from β-ketothioamides via bicyclization/ring-opening/oxidative coupling reaction

    C. Li, R. Liu, K. Yin, L. Wen and M. Li, Org. Biomol. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7OB00655A

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