Jump to main content
Jump to site search

Issue 27, 2017
Previous Article Next Article

Synthesis of disulfides tethered pyrroles from β-ketothioamides via a bicyclization/ring-opening/oxidative coupling reaction

Author affiliations

Abstract

A DABCO-promoted three-component reaction of β-ketothioamides (KTAs), arylglyoxals and 2-cyanoacetates to construct disulfides tethered pyrroles by using air as an oxidant has been disclosed. Importantly, this protocol involves a tandem sequence that includes Knoevenagel condensation, Michael addition, N-cyclization, O-cyclization, ring-opening and oxidative coupling.

Graphical abstract: Synthesis of disulfides tethered pyrroles from β-ketothioamides via a bicyclization/ring-opening/oxidative coupling reaction

Back to tab navigation

Supplementary files

Publication details

The article was received on 17 Mar 2017, accepted on 16 Jun 2017 and first published on 16 Jun 2017


Article type: Paper
DOI: 10.1039/C7OB00655A
Citation: Org. Biomol. Chem., 2017,15, 5820-5823
  •   Request permissions

    Synthesis of disulfides tethered pyrroles from β-ketothioamides via a bicyclization/ring-opening/oxidative coupling reaction

    C. Li, R. Liu, K. Yin, L. Wen and M. Li, Org. Biomol. Chem., 2017, 15, 5820
    DOI: 10.1039/C7OB00655A

Search articles by author

Spotlight

Advertisements