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Issue 20, 2017
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Copper-catalyzed fluoroalkylation of alkynes, and alkynyl & vinyl carboxylic acids with fluoroalkyl halides

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Abstract

Copper-catalyzed fluoroalkylation of alkynes and alkynyl carboxylic acids has been achieved with high functional-group tolerance and excellent regio- and stereoselectivities. A variety of fluoroalkyl halides including ethyl bromodifluoroacetate can be employed. Additionally, an unprecedented decarboxylative fluoroalkylation of α, β-unsaturated carboxylic acids has been achieved via a radical pathway.

Graphical abstract: Copper-catalyzed fluoroalkylation of alkynes, and alkynyl & vinyl carboxylic acids with fluoroalkyl halides

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Publication details

The article was received on 16 Mar 2017, accepted on 21 Apr 2017 and first published on 25 Apr 2017


Article type: Communication
DOI: 10.1039/C7OB00641A
Citation: Org. Biomol. Chem., 2017,15, 4295-4299
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    Copper-catalyzed fluoroalkylation of alkynes, and alkynyl & vinyl carboxylic acids with fluoroalkyl halides

    J. Ma and W. Yi, Org. Biomol. Chem., 2017, 15, 4295
    DOI: 10.1039/C7OB00641A

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