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Copper(I)-catalyzed ring-opening cyanation of cyclopropanols

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A copper(I)-catalyzed ring-opening cyanation of cyclopropanols was developed. The reaction provides an alternative method to achieve β-cyano ketones efficiently. This reaction exhibits good functional group compatibility under mild conditions and can be scaled up to the gram scale. Preliminary mechanistic studies suggest that the reaction might go through a free radical process.

Graphical abstract: Copper(i)-catalyzed ring-opening cyanation of cyclopropanols

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Publication details

The article was received on 14 Mar 2017, accepted on 06 Apr 2017 and first published on 06 Apr 2017

Article type: Communication
DOI: 10.1039/C7OB00627F
Citation: Org. Biomol. Chem., 2017, Advance Article
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    Copper(I)-catalyzed ring-opening cyanation of cyclopropanols

    Y. Feng, Y. Shu, P. Cao, T. Xu and H. Xu, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB00627F

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