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Regiocontrolled functionalization of 2,3-dihalogenoimidazo[1,2-a]pyridines by Suzuki–Miyaura and Sonogashira cross-coupling reactions

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Abstract

An efficient method for regiocontrolled functionalization of 2,3-dihalogenoimidazo[1,2-a]pyridine was developed. This sequence allowed the selective introduction of aryl, heteroaryl, alkyl and alkynyl substituents at both 2- and 3-positions, by using Suzuki–Miyaura and Sonogashira cross-coupling reactions. A library of compounds diversely substituted on 2- and 3-positions can be easily prepared from a common, stable and easily accessible starting material.

Graphical abstract: Regiocontrolled functionalization of 2,3-dihalogenoimidazo[1,2-a]pyridines by Suzuki–Miyaura and Sonogashira cross-coupling reactions

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Publication details

The article was received on 13 Mar 2017, accepted on 09 Apr 2017 and first published on 11 Apr 2017


Article type: Paper
DOI: 10.1039/C7OB00624A
Citation: Org. Biomol. Chem., 2017, Advance Article
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    Regiocontrolled functionalization of 2,3-dihalogenoimidazo[1,2-a]pyridines by Suzuki–Miyaura and Sonogashira cross-coupling reactions

    P.-O. Delaye, M. Pénichon, H. Allouchi, C. Enguehard-Gueiffier and A. Gueiffier, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB00624A

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