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A divergent and metal free synthesis of sulfoximine tethered imidazoles, imidazopyridines, imidazothiazoles, imidazobenzothiazines, thiazoles and selenazoles

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Abstract

A divergent and metal free approach has been successfully developed for the synthesis of sulfoximine tethered heterocycles. A key α-bromoalkanone intermediate 3b has been reported for the first time. Various sulfoximine tethered imidazoles, imidazopyridines, thiozoloimidazoles, imidazobenzothiazines, thiazoles and selenazoles are made from this common sulfoximine building block.

Graphical abstract: A divergent and metal free synthesis of sulfoximine tethered imidazoles, imidazopyridines, imidazothiazoles, imidazobenzothiazines, thiazoles and selenazoles

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Publication details

The article was received on 10 Mar 2017, accepted on 06 Apr 2017 and first published on 06 Apr 2017


Article type: Paper
DOI: 10.1039/C7OB00601B
Citation: Org. Biomol. Chem., 2017, Advance Article
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    A divergent and metal free synthesis of sulfoximine tethered imidazoles, imidazopyridines, imidazothiazoles, imidazobenzothiazines, thiazoles and selenazoles

    S. R. K. Battula, V. P. Rama Kishore Putta, G. V. Subbareddy, I. E. Chakravarthy and V. Saravanan, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB00601B

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