Issue 17, 2017

A divergent and metal free synthesis of sulfoximine tethered imidazoles, imidazopyridines, imidazothiazoles, imidazobenzothiazines, thiazoles and selenazoles

Abstract

A divergent and metal free approach has been successfully developed for the synthesis of sulfoximine tethered heterocycles. A key α-bromoalkanone intermediate 3b has been reported for the first time. Various sulfoximine tethered imidazoles, imidazopyridines, thiozoloimidazoles, imidazobenzothiazines, thiazoles and selenazoles are made from this common sulfoximine building block.

Graphical abstract: A divergent and metal free synthesis of sulfoximine tethered imidazoles, imidazopyridines, imidazothiazoles, imidazobenzothiazines, thiazoles and selenazoles

Supplementary files

Article information

Article type
Paper
Submitted
10 Mar 2017
Accepted
06 Apr 2017
First published
06 Apr 2017

Org. Biomol. Chem., 2017,15, 3742-3755

A divergent and metal free synthesis of sulfoximine tethered imidazoles, imidazopyridines, imidazothiazoles, imidazobenzothiazines, thiazoles and selenazoles

S. R. K. Battula, V. P. Rama Kishore Putta, G. V. Subbareddy, I. E. Chakravarthy and V. Saravanan, Org. Biomol. Chem., 2017, 15, 3742 DOI: 10.1039/C7OB00601B

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