Jump to main content
Jump to site search

Issue 18, 2017
Previous Article Next Article

Copper-catalysed enantioselective Michael addition of malonic esters to β-trifluoromethyl-α,β-unsaturated imines

Author affiliations

Abstract

Copper triflate-BOX complexes catalyse the enantioselective conjugate addition of methyl malonate to β-trifluoromethyl-α,β-unsaturated imines to give the corresponding enamines bearing a trifluoromethylated stereogenic centre with good yields, and diastereo- and enantioselectivities. The usefulness of the method has been shown with the synthesis of optically active β-trifluoromethyl δ-amino esters and optically active trifluoromethyl piperidones.

Graphical abstract: Copper-catalysed enantioselective Michael addition of malonic esters to β-trifluoromethyl-α,β-unsaturated imines

Back to tab navigation

Supplementary files

Publication details

The article was received on 09 Mar 2017, accepted on 06 Apr 2017 and first published on 06 Apr 2017


Article type: Communication
DOI: 10.1039/C7OB00595D
Citation: Org. Biomol. Chem., 2017,15, 3849-3853
  •   Request permissions

    Copper-catalysed enantioselective Michael addition of malonic esters to β-trifluoromethyl-α,β-unsaturated imines

    M. Espinosa, J. Herrera, G. Blay, L. Cardona, M. C. Muñoz and J. R. Pedro, Org. Biomol. Chem., 2017, 15, 3849
    DOI: 10.1039/C7OB00595D

Search articles by author

Spotlight

Advertisements