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Issue 16, 2017
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Amidation of unactivated ester derivatives mediated by trifluoroethanol

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Abstract

A catalytic amidation protocol mediated by 2,2,2-trifluoroethanol has been developed, facilitating the condensation of unactivated esters and amines, furnishing both secondary and tertiary amides. The complete scope and limitations of the method are described, along with modified conditions for challenging substrates such as acyclic secondary amines and chiral esters with retention of chiral integrity.

Graphical abstract: Amidation of unactivated ester derivatives mediated by trifluoroethanol

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Publication details

The article was received on 09 Mar 2017, accepted on 04 Apr 2017 and first published on 04 Apr 2017


Article type: Paper
DOI: 10.1039/C7OB00593H
Citation: Org. Biomol. Chem., 2017,15, 3507-3518
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    Amidation of unactivated ester derivatives mediated by trifluoroethanol

    C. G. McPherson, N. Caldwell, C. Jamieson, I. Simpson and A. J. B. Watson, Org. Biomol. Chem., 2017, 15, 3507
    DOI: 10.1039/C7OB00593H

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