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Synthesis of AHMOD-containing aminolipopeptides, unique bioactive peptaibiotics

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Abstract

An interesting family of bioactive aminolipopeptides contain the unusual building block 2-amino-6-hydroxy-4-methyl-8-oxodecanoic acid (AHMOD). This building block has presented a significant challenge to synthesis of this family of aminolipopeptides due to the sensitive β-hydroxyketone motif present. The discovery and identification, syntheses, and eventual incorporation of synthetically challenging AHMOD into selected aminolipopeptides is described herein.

Graphical abstract: Synthesis of AHMOD-containing aminolipopeptides, unique bioactive peptaibiotics

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Publication details

The article was received on 03 Mar 2017, accepted on 06 Apr 2017 and first published on 06 Apr 2017


Article type: Review Article
DOI: 10.1039/C7OB00541E
Citation: Org. Biomol. Chem., 2017, Advance Article
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    Synthesis of AHMOD-containing aminolipopeptides, unique bioactive peptaibiotics

    L. A. Stubbing, I. Kavianinia and M. A. Brimble, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB00541E

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