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A highly selective and sensitive fluorescent probe for Cu2+ based on a novel naphthalimide–rhodamine platform and its application in live cell imaging

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Abstract

Copper plays important roles in a variety of fundamental physiological processes. At the cell organelle level, aberrant copper homeostasis in lysosomes can lead to various serious diseases. Herein, a bifluorophore-based, lysosome-targetable Cu2+-selective ratiometric fluorescent probe (V) has been synthesized by reasonable design. The probe V shows high selectivity toward Cu2+ ions over other cations and exhibits high sensitivity (1.45 nM) for the detection of Cu2+ ions. Meanwhile, the probe is cell permeable and suitable for ratiometric visualization of lysosomal Cu2+ in the living cell.

Graphical abstract: A highly selective and sensitive fluorescent probe for Cu2+ based on a novel naphthalimide–rhodamine platform and its application in live cell imaging

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Publication details

The article was received on 03 Mar 2017, accepted on 11 Apr 2017 and first published on 12 Apr 2017


Article type: Paper
DOI: 10.1039/C7OB00538E
Citation: Org. Biomol. Chem., 2017, Advance Article
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    A highly selective and sensitive fluorescent probe for Cu2+ based on a novel naphthalimide–rhodamine platform and its application in live cell imaging

    C. Liu, X. Jiao, S. He, L. Zhao and X. Zeng, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB00538E

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