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Issue 15, 2017
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A tunable copper-catalyzed multicomponent reaction towards alkaloid-inspired indole/lactam polycycles

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Abstract

A versatile copper(I)-catalyzed cascade multicomponent reaction strategy between readily available (Z)-3-iodoacrylic acids, terminal alkynes, and primary amines is reported, leading to a great diversity of complex heterocyclic backbones based on biorelevant indole/lactam scaffolds.

Graphical abstract: A tunable copper-catalyzed multicomponent reaction towards alkaloid-inspired indole/lactam polycycles

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Publication details

The article was received on 02 Mar 2017, accepted on 17 Mar 2017 and first published on 17 Mar 2017


Article type: Paper
DOI: 10.1039/C7OB00532F
Citation: Org. Biomol. Chem., 2017,15, 3304-3309
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    A tunable copper-catalyzed multicomponent reaction towards alkaloid-inspired indole/lactam polycycles

    M. I. D. Mardjan, S. Perie, J.-L. Parrain and L. Commeiras, Org. Biomol. Chem., 2017, 15, 3304
    DOI: 10.1039/C7OB00532F

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