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Synthesis of fused cyanopyrroles and spirocyclopropanes via addition of N-ylides to chalconimines

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Abstract

Addition of N-ylides derived from DABCO to chalconimines takes place through a Michael addition–cyclization pathway to afford fused cyanopyrroles and/or spirocyclopropanes. The product profile depends heavily on the nature of chalconimines. While 6-membered cyclic chalconimines provide a mixture of pyrrole and spirocyclopropane, 5-membered chalconimines furnish exclusively spirocyclopropane. Cyclopropane was the only product in the case of a representative open chain chalconimine as well. On the other hand, chalcones provide only spirocyclopropanes which is in contrast to the previously reported reactivity of enones. The complementary nature of the reactivity of the tetralone derived chalcone and its corresponding imine in providing spirocyclopropane and pyrrole, respectively, has also been demonstrated.

Graphical abstract: Synthesis of fused cyanopyrroles and spirocyclopropanes via addition of N-ylides to chalconimines

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Publication details

The article was received on 02 Mar 2017, accepted on 04 Apr 2017 and first published on 04 Apr 2017


Article type: Paper
DOI: 10.1039/C7OB00529F
Citation: Org. Biomol. Chem., 2017, Advance Article
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    Synthesis of fused cyanopyrroles and spirocyclopropanes via addition of N-ylides to chalconimines

    S. P. Midya, E. Gopi, N. Satam and I. N. N. Namboothiri, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB00529F

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