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PhI(OAc)2-mediated 1,2-aminohalogenation of alkynes: a general access to (E)-4-(halomethylene)oxazolidin-2-ones

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Abstract

A new PhI(OAc)2-mediated 1,2-aminohalogenation of prop-2-yn-1-yl carbamates and various halogen sources is presented with excellent selectivity and high step-economy. The reaction is general and rapid for the construction of diverse (E)-4-(halomethylene)oxazolidin-2-ones through the generation of the three-membered ring or N-radical followed by intramolecular cyclization.

Graphical abstract: PhI(OAc)2-mediated 1,2-aminohalogenation of alkynes: a general access to (E)-4-(halomethylene)oxazolidin-2-ones

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Publication details

The article was received on 28 Feb 2017, accepted on 05 Apr 2017 and first published on 06 Apr 2017


Article type: Paper
DOI: 10.1039/C7OB00509A
Citation: Org. Biomol. Chem., 2017, Advance Article
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    PhI(OAc)2-mediated 1,2-aminohalogenation of alkynes: a general access to (E)-4-(halomethylene)oxazolidin-2-ones

    R. Wang, H. Zou, Y. Xiong, N. Yi, W. Deng and J. Xiang, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB00509A

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