Jump to main content
Jump to site search

Issue 17, 2017
Previous Article Next Article

Brønsted acid-catalyzed, enantioselective synthesis of 1,4-dihydroquinoline-3-carboxylates via in situ generated ortho-quinone methide imines

Author affiliations

Abstract

A straightforward, catalytic, enantioselective approach toward the synthesis of a broad range of 1,4-dihydroquinoline-3-carboxylates is described. Under phosphoric acid catalysis in situ-generated ortho-quinone methide imines reacted with β-keto esters to form the nitrogen heterocycles with good yields and enantioselectivities in just one synthetic step under ambient reactions conditions.

Graphical abstract: Brønsted acid-catalyzed, enantioselective synthesis of 1,4-dihydroquinoline-3-carboxylates via in situ generated ortho-quinone methide imines

Back to tab navigation

Supplementary files

Publication details

The article was received on 27 Feb 2017, accepted on 07 Apr 2017 and first published on 07 Apr 2017


Article type: Paper
DOI: 10.1039/C7OB00488E
Citation: Org. Biomol. Chem., 2017,15, 3706-3716
  •   Request permissions

    Brønsted acid-catalyzed, enantioselective synthesis of 1,4-dihydroquinoline-3-carboxylates via in situ generated ortho-quinone methide imines

    T. Hodík and C. Schneider, Org. Biomol. Chem., 2017, 15, 3706
    DOI: 10.1039/C7OB00488E

Search articles by author

Spotlight

Advertisements