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Dissecting the structural basis for the intracellular delivery of OSW-1 by fluorescent probes

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Abstract

The structural basis for the intracellular delivery of OSW-1 is investigated using fluorescent derivatives of OSW-1 and its closely related congeners. Despite the large differences in activity, all the fluorescent probes are found to translocate across the plasma membrane to the ER and Golgi apparatus. This observation suggests that the glycosylated cholestane moiety plays an important role in the cell internalization and intracellular localization property of OSW-1.

Graphical abstract: Dissecting the structural basis for the intracellular delivery of OSW-1 by fluorescent probes

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Publication details

The article was received on 27 Feb 2017, accepted on 14 Mar 2017 and first published on 27 Mar 2017


Article type: Communication
DOI: 10.1039/C7OB00486A
Citation: Org. Biomol. Chem., 2017, Advance Article
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    Dissecting the structural basis for the intracellular delivery of OSW-1 by fluorescent probes

    M. Hiraizumi, R. Komatsu, T. Shibata, Y. Ohta and K. Sakurai, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB00486A

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