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Enantioselective [4 + 1] cycloaddition of ortho-quinone methides and bromomalonates under phase-transfer catalysis

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Abstract

An enantioselective [4 + 1] cycloaddition reaction of ortho-quinone methides and bromomalonates using a quinine and BINOL derived phase-transfer catalyst is described. With high yields and enantioselectivities, the method provided a variety of optically active dihydrobenzofurans, which represent a valuable structural motif present in numerous naturally occurring and biologically active molecules.

Graphical abstract: Enantioselective [4 + 1] cycloaddition of ortho-quinone methides and bromomalonates under phase-transfer catalysis

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Publication details

The article was received on 27 Feb 2017, accepted on 05 Apr 2017 and first published on 05 Apr 2017


Article type: Paper
DOI: 10.1039/C7OB00484B
Citation: Org. Biomol. Chem., 2017, Advance Article
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    Enantioselective [4 + 1] cycloaddition of ortho-quinone methides and bromomalonates under phase-transfer catalysis

    X. Lian, A. Adili, B. Liu, Z. Tao and Z. Han, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB00484B

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