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Issue 12, 2017
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Base-mediated insertion reaction of alkynes into carbon–carbon σ-bonds of ethanones: synthesis of hydroxydienone and chromone derivatives

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Abstract

Transition-metal free insertions of alkynes into carbon–carbon σ-bonds of ethanones have been reported. These tandem reactions offer an efficient synthesis of hydroxydienones and multi-substituted chromones. This is the first example of base-promoted insertion reactions of isolated carbon–carbon triple bonds into carbon–carbon σ-bonds with active methylene compounds bearing only one electron-withdrawing group.

Graphical abstract: Base-mediated insertion reaction of alkynes into carbon–carbon σ-bonds of ethanones: synthesis of hydroxydienone and chromone derivatives

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Publication details

The article was received on 25 Feb 2017, accepted on 28 Feb 2017 and first published on 07 Mar 2017


Article type: Communication
DOI: 10.1039/C7OB00476A
Citation: Org. Biomol. Chem., 2017,15, 2497-2500
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    Base-mediated insertion reaction of alkynes into carbon–carbon σ-bonds of ethanones: synthesis of hydroxydienone and chromone derivatives

    F. Zhang, Q. Yao, Y. Yuan, M. Xu, L. Kong and Y. Li, Org. Biomol. Chem., 2017, 15, 2497
    DOI: 10.1039/C7OB00476A

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