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Issue 14, 2017
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A dual removable activating group enabled the Povarov reaction of N-arylalanine esters: synthesis of quinoline-4-carboxylate esters

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Abstract

A dual removable activating group enabled Povarov reaction of N-arylalanine esters was reported. N-Arylalanine ester was utilized as the sole carbon source to generate N-arylimine and its tautomer, enamine, in situ by aerobic oxidation of sp3 C–H bonds, and then the consecutive reaction delivered the desired quinoline-4-carboxylate esters in high yields.

Graphical abstract: A dual removable activating group enabled the Povarov reaction of N-arylalanine esters: synthesis of quinoline-4-carboxylate esters

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Publication details

The article was received on 23 Feb 2017, accepted on 08 Mar 2017 and first published on 08 Mar 2017


Article type: Paper
DOI: 10.1039/C7OB00446J
Citation: Org. Biomol. Chem., 2017,15, 2931-2937
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    A dual removable activating group enabled the Povarov reaction of N-arylalanine esters: synthesis of quinoline-4-carboxylate esters

    X. Jia, S. Lü, Y. Yuan, X. Zhang, L. Zhang and L. Luo, Org. Biomol. Chem., 2017, 15, 2931
    DOI: 10.1039/C7OB00446J

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