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An Ir(III)-catalyzed aryl C–H bond carbenoid functionalization cascade: access to 1,3-dihydroindol-2-ones

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Abstract

An Ir(III)-catalyzed relay aryl C–H bond carbenoid insertion cascade of N-aryl-2-pyridinamines with diazo Meldrum's acid has been developed. This method provides an efficient approach to multifunctionalized 1,3-dihydroindol-2-ones with a broad range of functional group tolerance. Furthermore, this protocol could be applied for the concise synthesis of bioactive hematopoietic growth factor analogues.

Graphical abstract: An Ir(iii)-catalyzed aryl C–H bond carbenoid functionalization cascade: access to 1,3-dihydroindol-2-ones

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Publication details

The article was received on 15 Feb 2017, accepted on 03 Apr 2017 and first published on 03 Apr 2017


Article type: Paper
DOI: 10.1039/C7OB00367F
Citation: Org. Biomol. Chem., 2017, Advance Article
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    An Ir(III)-catalyzed aryl C–H bond carbenoid functionalization cascade: access to 1,3-dihydroindol-2-ones

    S. Bai, X. Chen, X. Hu, Y. Deng, H. Jiang and W. Zeng, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB00367F

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