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Issue 22, 2017
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Total synthesis of marine natural products separacenes A and B

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Abstract

A short and convergent route for the stereoselective total synthesis of separacenes A and B has been developed using (+)-methyl D-lactate and D-(−)-tartaric acid as the chiral pools. The characteristic features of this synthesis include the Trost–Rychnovsky alkyne rearrangement to construct the C7–C9 conjugated diene, the Horner–Wadsworth–Emmons olefination to form the C5–C6 and C11–C12 olefins and the Corey–Bakshi–Shibata reaction to install the C-13 hydroxy functionality.

Graphical abstract: Total synthesis of marine natural products separacenes A and B

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Publication details

The article was received on 13 Feb 2017, accepted on 16 May 2017 and first published on 16 May 2017


Article type: Paper
DOI: 10.1039/C7OB00345E
Citation: Org. Biomol. Chem., 2017,15, 4842-4850
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    Total synthesis of marine natural products separacenes A and B

    S. Das and R. K. Goswami, Org. Biomol. Chem., 2017, 15, 4842
    DOI: 10.1039/C7OB00345E

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