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Issue 15, 2017
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Synthesis of pyrrolo[1,2-a]naphthyridines by Lewis acid mediated cycloisomerization

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Abstract

Pyrrolo[1,2-a]naphthyridines were synthesized from 3-alkynyl-2-([1H]-pyrrol-1-yl)pyridines and 3-alkynyl-4-([1H]-pyrrol-1-yl)pyridines by cycloisomerization. The reactions are performed by application of the Lewis acids PtCl2 or Bi(OTf)3 without the need of further additives. With the described methods a number of derivatives containing a variety of functional groups have been synthesized in up to 78% yield.

Graphical abstract: Synthesis of pyrrolo[1,2-a]naphthyridines by Lewis acid mediated cycloisomerization

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Publication details

The article was received on 13 Feb 2017, accepted on 15 Mar 2017 and first published on 16 Mar 2017


Article type: Paper
DOI: 10.1039/C7OB00343A
Citation: Org. Biomol. Chem., 2017,15, 3216-3231
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    Synthesis of pyrrolo[1,2-a]naphthyridines by Lewis acid mediated cycloisomerization

    A. Flader, S. Parpart, P. Ehlers and P. Langer, Org. Biomol. Chem., 2017, 15, 3216
    DOI: 10.1039/C7OB00343A

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