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Issue 18, 2017
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Thiolysis of NBD-based dyes for colorimetric and fluorescence detection of H2S and biothiols: design and biological applications

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Abstract

Hydrogen sulfide (H2S) is an important endogenous signaling molecule with multiple biological functions. The development of colorimetric and fluorescent probes for the visualization of H2S is useful for studying H2S biology. This review details up-to-date research on H2S probes based on thiolysis reactions of NBD (7-nitro-1,2,3-benzoxadiazole) amines or ethers (thioethers). The reactivity and selectivity of NBD-based dyes are discussed. The design principles of NBD-based probes are highlighted. The advantages and disadvantages of NBD-based probes are compared, and their biological applications are discussed.

Graphical abstract: Thiolysis of NBD-based dyes for colorimetric and fluorescence detection of H2S and biothiols: design and biological applications

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Publication details

The article was received on 12 Feb 2017, accepted on 21 Mar 2017 and first published on 21 Mar 2017


Article type: Review Article
DOI: 10.1039/C7OB00332C
Citation: Org. Biomol. Chem., 2017,15, 3828-3839
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    Thiolysis of NBD-based dyes for colorimetric and fluorescence detection of H2S and biothiols: design and biological applications

    L. Yi and Z. Xi, Org. Biomol. Chem., 2017, 15, 3828
    DOI: 10.1039/C7OB00332C

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