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Issue 13, 2017
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Phenacyl azides as efficient intermediates: one-pot synthesis of pyrrolidines and imidazoles

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Abstract

Phenacyl azides were decomposed in basic media to generate N-unsubstituted imines which were reacted with cyclic amino acids to give an azomethine ylide that underwent [3 + 2] cycloaddition with maleimides and N-unsubstituted imines to yield various diastereoselective pyrrolidines and imidazoles respectively in a one-pot three component manner with good to excellent yields.

Graphical abstract: Phenacyl azides as efficient intermediates: one-pot synthesis of pyrrolidines and imidazoles

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Publication details

The article was received on 08 Feb 2017, accepted on 09 Mar 2017 and first published on 09 Mar 2017


Article type: Communication
DOI: 10.1039/C7OB00299H
Citation: Org. Biomol. Chem., 2017,15, 2730-2733
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    Phenacyl azides as efficient intermediates: one-pot synthesis of pyrrolidines and imidazoles

    C. N. Reddy, M. Sathish, S. Adhikary, J. B. Nanubolu, A. Alarifi, R. A. Maurya and A. Kamal, Org. Biomol. Chem., 2017, 15, 2730
    DOI: 10.1039/C7OB00299H

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