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Issue 16, 2017
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nBu4NI-Mediated oxidation of methyl ketones to α-ketoamides: using ammonium, primary and secondary amine-salt as an amine moiety

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Abstract

Presented here is the first example of synthesizing an array of primary-, secondary-, and tertiary-α-ketoamides with a non-metal catalyst nBu4NI from methyl ketones and inexpensive readily available amine/ammonium salts; the reactions proceeded smoothly under mild conditions, TBHP was used as an oxidant and the corresponding α-ketoamides were afforded in moderate to excellent yields.

Graphical abstract: nBu4NI-Mediated oxidation of methyl ketones to α-ketoamides: using ammonium, primary and secondary amine-salt as an amine moiety

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Publication details

The article was received on 04 Feb 2017, accepted on 06 Mar 2017 and first published on 06 Mar 2017


Article type: Paper
DOI: 10.1039/C7OB00270J
Citation: Org. Biomol. Chem., 2017,15, 3427-3434
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    nBu4NI-Mediated oxidation of methyl ketones to α-ketoamides: using ammonium, primary and secondary amine-salt as an amine moiety

    D. Wang, K. Zhang, L. Jia, D. Zhang, Y. Zhang, Y. Cheng, C. Lin and B. Wang, Org. Biomol. Chem., 2017, 15, 3427
    DOI: 10.1039/C7OB00270J

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