Issue 10, 2017
From the journal:

Organic & Biomolecular Chemistry

Thermolysis and radiofluorination of diaryliodonium salts derived from anilines†

Ethan J. Linstad,ab   Amy L. Vāvere,c   Bao Hu,b   Jayson J. Kempinger,a   Scott E. Snyderc  and  Stephen G. DiMagno ORCID logo *b  

* Corresponding authors

a Department of Chemistry, University of Nebraska–Lincoln, Lincoln, Nebraska 68588, USA

b Departments of Medicinal Chemistry & Pharmacognosy and Chemistry, University of Illinois–Chicago, Chicago, Illinois 60612, USA
E-mail: sdimagno@uic.edu

c Division of Nuclear Medicine, Department of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA

Abstract

Aniline-derived diaryliodonium salts were synthesized and functionalized in good to excellent yields by judicious utilization of electron-withdrawing protecting groups. This simple approach opens another route to radiolabeling amino arenes in relatively complex molecules, such as flutemetamol.

Graphical abstract: Thermolysis and radiofluorination of diaryliodonium salts derived from anilines

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Article information

DOI
https://doi.org/10.1039/C7OB00253J
Article type
Paper
Submitted
01 Feb 2017
Accepted
17 Feb 2017
First published
17 Feb 2017

Org. Biomol. Chem., 2017,15, 2246-2252

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Thermolysis and radiofluorination of diaryliodonium salts derived from anilines

E. J. Linstad, A. L. Vāvere, B. Hu, J. J. Kempinger, S. E. Snyder and S. G. DiMagno, Org. Biomol. Chem., 2017, 15, 2246 DOI: 10.1039/C7OB00253J

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