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Issue 12, 2017
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Copper-catalyzed TEMPO oxidative cleavage of 1,3-diketones and β-keto esters for the synthesis of 1,2-diketones and α-keto esters

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Abstract

A copper-catalyzed efficient and practical method has been developed for the synthesis of 1,2-diketones and α-keto esters. TEMPO was used as a radical initiator and scavenger, oxidizing the cleavage of α-methylene of 1,3-diketones and β-keto esters to form 1,2-diketones and α-keto esters. This method provided a general way for the formation of 1,2-dicarbonyl compounds.

Graphical abstract: Copper-catalyzed TEMPO oxidative cleavage of 1,3-diketones and β-keto esters for the synthesis of 1,2-diketones and α-keto esters

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Publication details

The article was received on 31 Jan 2017, accepted on 28 Feb 2017 and first published on 28 Feb 2017


Article type: Paper
DOI: 10.1039/C7OB00241F
Citation: Org. Biomol. Chem., 2017,15, 2629-2637
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    Copper-catalyzed TEMPO oxidative cleavage of 1,3-diketones and β-keto esters for the synthesis of 1,2-diketones and α-keto esters

    P. Zhou, C. Li, S. Zhou, A. Shoberu and J. Zou, Org. Biomol. Chem., 2017, 15, 2629
    DOI: 10.1039/C7OB00241F

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