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Issue 11, 2017
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Isoafricanol synthase from Streptomyces malaysiensis

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Abstract

Genome sequencing of Streptomyces malaysiensis DSM 4137 revealed the presence of four terpene cyclase genes, one of which was characterised as (+)-isoafricanol synthase. Its cyclisation mechanism was extensively studied using isotopically labelled precursors. Several enzymes with high homology that likely also function as (+)-isoafricanol synthases are encoded in a number of other genome sequenced streptomycetes.

Graphical abstract: Isoafricanol synthase from Streptomyces malaysiensis

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Publication details

The article was received on 30 Jan 2017, accepted on 20 Feb 2017 and first published on 01 Mar 2017


Article type: Communication
DOI: 10.1039/C7OB00234C
Citation: Org. Biomol. Chem., 2017,15, 2353-2358
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    Isoafricanol synthase from Streptomyces malaysiensis

    P. Rabe, M. Samborskyy, P. F. Leadlay and J. S. Dickschat, Org. Biomol. Chem., 2017, 15, 2353
    DOI: 10.1039/C7OB00234C

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