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Issue 12, 2017
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Isolation and structure elucidation of natural products of three soft corals and a sponge from the coast of Madagascar

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Abstract

We investigated the three soft corals Sarcophyton stellatum, Capnella fungiformis and Lobophytum crassum and the sponge Pseudoceratina arabica, which have been collected at the coast of Madagascar. In addition to previously known marine natural products, S. stellatum provided the new (+)-enantiomer of the cembranoid (1E,3E,11E)-7,8-epoxycembra-1,3,11,15-tetraene (2). Capnella fungiformis afforded three new natural products, ethyl 5-[(1E,5Z)-2,6-dimethylocta-1,5,7-trienyl]furan-3-carboxylate (6), ethyl 5-[(1E,5E)-2,6-dimethylocta-1,5,7-trienyl]furan-3-carboxylate (7) and the diepoxyguaiane sesquiterpene oxyfungiformin (9a). The extracts of all three soft corals exhibited moderate activities against the malarial parasite Plasmodium falciparum. Extracts of the sponge Pseudoceratina arabica proved to be very active against a series of Gram-positive and Gram-negative bacteria.

Graphical abstract: Isolation and structure elucidation of natural products of three soft corals and a sponge from the coast of Madagascar

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Publication details

The article was received on 24 Jan 2017, accepted on 24 Feb 2017, published on 24 Feb 2017 and first published online on 24 Feb 2017


Article type: Paper
DOI: 10.1039/C7OB00191F
Citation: Org. Biomol. Chem., 2017,15, 2593-2608
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    Isolation and structure elucidation of natural products of three soft corals and a sponge from the coast of Madagascar

    M. P. Rahelivao, T. Lübken, M. Gruner, O. Kataeva, R. Ralambondrahety, H. Andriamanantoanina, M. P. Checinski, I. Bauer and H. Knölker, Org. Biomol. Chem., 2017, 15, 2593
    DOI: 10.1039/C7OB00191F

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