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A decade of DNA-hybrid catalysis: from innovation to comprehension

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Abstract

In a little over a decade, the unique chirality of oligonucleotides has allowed the development of a variety of asymmetric synthetic transformations. The concept lies in embedding an achiral transition metal catalyst in a DNA double helix, which provides the necessary chiral microenvironment to selectively form one enantiomer of a given reaction product. The most recent efforts at unveiling new reactivities have been accompanied by the desire to understand the mechanisms by which the chirality is transferred and the influence of the interaction between DNA and the metallic co-factor on the selectivity. By offering a complete overview of the field, this review aims to highlight the intricate correlation between the structure of the chiral bio-inorganic scaffold and its catalytic efficacy.

Graphical abstract: A decade of DNA-hybrid catalysis: from innovation to comprehension

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Publication details

The article was received on 22 Jan 2017, accepted on 23 Apr 2017 and first published on 25 Apr 2017


Article type: Review Article
DOI: 10.1039/C7OB00176B
Citation: Org. Biomol. Chem., 2017, Advance Article
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    A decade of DNA-hybrid catalysis: from innovation to comprehension

    N. Duchemin, I. Heath-Apostolopoulos, M. Smietana and S. Arseniyadis, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB00176B

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