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Issue 12, 2017
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Comparative pharmacokinetic profile of cyclosporine (CsA) with a decapeptide and a linear analogue

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Abstract

The synthesis and in vivo pharmacokinetic profile of an analogue of cyclosporine is disclosed. An acyclic congener was also profiled in in vitro assays to compare cell permeability. The compounds possess similar calculated and measured molecular descriptors however have different behaviors in an RRCK assay to assess cell permeability.

Graphical abstract: Comparative pharmacokinetic profile of cyclosporine (CsA) with a decapeptide and a linear analogue

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Publication details

The article was received on 14 Jan 2017, accepted on 24 Feb 2017 and first published on 07 Mar 2017


Article type: Communication
DOI: 10.1039/C7OB00096K
Citation: Org. Biomol. Chem., 2017,15, 2501-2506
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    Comparative pharmacokinetic profile of cyclosporine (CsA) with a decapeptide and a linear analogue

    D. A. Price, H. Eng, K. A. Farley, G. H. Goetz, Y. Huang, Z. Jiao, A. S. Kalgutkar, N. M. Kablaoui, B. Khunte, S. Liras, C. Limberakis, A. M. Mathiowetz, R. B. Ruggeri, J. Quan and Z. Yang, Org. Biomol. Chem., 2017, 15, 2501
    DOI: 10.1039/C7OB00096K

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