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Issue 12, 2017
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Ligand-free Cu(II)-mediated aerobic oxidations of aldehyde hydrazones leading to N,N′-diacylhydrazines and 1,3,4-oxadiazoles

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Abstract

A Cu(II)-mediated synthesis of N,N′-diacylhydrazines and 1,3,4-oxadiazoles from aldehyde hydrazones has been developed. This is the first time that the synthesis of N,N′-diacylhydrazines and 1,3,4-oxadiazoles using N,N-dimethylamides as the acylation reagent and O2 in air as the oxidation reagent is reported. These reactions offered several advantages including simple workups, ligand-free inexpensive metal salts as mediators, high yields, and wide scope of substrates.

Graphical abstract: Ligand-free Cu(ii)-mediated aerobic oxidations of aldehyde hydrazones leading to N,N′-diacylhydrazines and 1,3,4-oxadiazoles

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Publication details

The article was received on 07 Jan 2017, accepted on 28 Feb 2017 and first published on 28 Feb 2017


Article type: Paper
DOI: 10.1039/C7OB00042A
Citation: Org. Biomol. Chem., 2017,15, 2585-2592
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    Ligand-free Cu(II)-mediated aerobic oxidations of aldehyde hydrazones leading to N,N′-diacylhydrazines and 1,3,4-oxadiazoles

    L. Liu and S. Feng, Org. Biomol. Chem., 2017, 15, 2585
    DOI: 10.1039/C7OB00042A

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