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Issue 15, 2017
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A study of diketopiperazines as electron-donor initiators in transition metal-free haloarene–arene coupling

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Abstract

Several diketopiperazines have been shown to promote carbon–carbon coupling between benzene and aryl halides in the presence of potassium tert-butoxide and without the assistance of a transition metal catalyst. The structure of the diketopiperazine has an influence on its reductive potential and can help to promote the coupling of the more challenging aryl bromides with benzene.

Graphical abstract: A study of diketopiperazines as electron-donor initiators in transition metal-free haloarene–arene coupling

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Publication details

The article was received on 06 Jan 2017, accepted on 21 Mar 2017 and first published on 29 Mar 2017


Article type: Paper
DOI: 10.1039/C7OB00036G
Citation: Org. Biomol. Chem., 2017,15, 3324-3336
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    A study of diketopiperazines as electron-donor initiators in transition metal-free haloarene–arene coupling

    F. Cumine, S. Zhou, T. Tuttle and J. A. Murphy, Org. Biomol. Chem., 2017, 15, 3324
    DOI: 10.1039/C7OB00036G

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