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Issue 12, 2017
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One-pot synthesis of α,β-epoxy ketones through domino reaction between alkenes and aldehydes catalyzed by proline based chiral organocatalysts

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Abstract

Proline based metal free organocatalysts were developed by using a new approach for the synthesis of epoxide derivatives through a domino reaction. This domino reaction (oxidative coupling) allows a direct access to epoxides from various alkenes and aldehydes through C–H functionalization and C–C/C–O bond formation. The catalytic efficiencies of the newly synthesized organocatalysts were also determined by domino reaction in the presence of various functional groups containing aldehyde and alkene derivatives with very good yields (up to 95%) and ee's (up to 99%).

Graphical abstract: One-pot synthesis of α,β-epoxy ketones through domino reaction between alkenes and aldehydes catalyzed by proline based chiral organocatalysts

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Publication details

The article was received on 06 Jan 2017, accepted on 09 Feb 2017, published on 09 Feb 2017 and first published online on 09 Feb 2017


Article type: Paper
DOI: 10.1039/C7OB00031F
Citation: Org. Biomol. Chem., 2017,15, 2551-2561
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    One-pot synthesis of α,β-epoxy ketones through domino reaction between alkenes and aldehydes catalyzed by proline based chiral organocatalysts

    V. Ashokkumar and A. Siva, Org. Biomol. Chem., 2017, 15, 2551
    DOI: 10.1039/C7OB00031F

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