Issue 6, 2017

Fluorinated trimethyllysine as a 19F NMR probe for trimethyllysine hydroxylase catalysis

Abstract

Trimethyllysine hydroxylase (TMLH) catalyses C-3 hydroxylation of Nε-trimethyllysine in the first step of carnitine biosynthesis in humans. Studies on TMLH have been hampered by the lack of established chemical methods. We report that an Nε-trimethyllysine analogue that contains the fluoromethyl group can be used as a 1H and 19F NMR probe for studies on TMLH catalysis.

Graphical abstract: Fluorinated trimethyllysine as a 19F NMR probe for trimethyllysine hydroxylase catalysis

Supplementary files

Article information

Article type
Communication
Submitted
08 Dec 2016
Accepted
17 Jan 2017
First published
17 Jan 2017

Org. Biomol. Chem., 2017,15, 1350-1354

Fluorinated trimethyllysine as a 19F NMR probe for trimethyllysine hydroxylase catalysis

Y. Vijayendar Reddy, A. H. K. Al Temimi and J. Mecinović, Org. Biomol. Chem., 2017, 15, 1350 DOI: 10.1039/C6OB02683D

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