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Issue 28, 2017
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One-step synthesis of conjugated enynenitriles from bromocyanoacetylene

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Abstract

The chemical reactivity of bromocyanoacetylene has been evaluated for the first time by making it react with terminal alkynes and secondary amines in the presence of bis(triphenylphosphine)palladium dichloride and copper iodide as co-catalysts. This reaction provides new conjugated enynenitriles stereoselectively in one step in variable yields.

Graphical abstract: One-step synthesis of conjugated enynenitriles from bromocyanoacetylene

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Publication details

The article was received on 25 Nov 2016, accepted on 27 Jun 2017 and first published on 06 Jul 2017


Article type: Paper
DOI: 10.1039/C6OB02590K
Citation: Org. Biomol. Chem., 2017,15, 6050-6056
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    One-step synthesis of conjugated enynenitriles from bromocyanoacetylene

    R. Ligny, E. S. Gauthier, M. Yáñez, T. Roisnel, J. Guillemin and Y. Trolez, Org. Biomol. Chem., 2017, 15, 6050
    DOI: 10.1039/C6OB02590K

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