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Issue 2, 2017
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Improving cell penetration of helical peptides stabilized by N-terminal crosslinked aspartic acids

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Abstract

Cell penetration and nucleus translocation efficiency are important for the cellular activities of peptide therapeutics. For helical peptides stabilized by N-terminal crosslinked aspartic acid, correlations between their penetration efficiency/nucleus translocation and physicochemical properties were studied. An increase in hydrophobicity and isoelectric point will promote cellular uptake and nucleus translocation of stabilized helices.

Graphical abstract: Improving cell penetration of helical peptides stabilized by N-terminal crosslinked aspartic acids

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Publication details

The article was received on 16 Nov 2016, accepted on 30 Nov 2016 and first published on 07 Dec 2016


Article type: Paper
DOI: 10.1039/C6OB02501C
Citation: Org. Biomol. Chem., 2017,15, 459-464
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    Improving cell penetration of helical peptides stabilized by N-terminal crosslinked aspartic acids

    H. Zhao, Y. Jiang, Y. Tian, D. Yang, X. Qin and Z. Li, Org. Biomol. Chem., 2017, 15, 459
    DOI: 10.1039/C6OB02501C

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