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Issue 3, 2017
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Synthesis and physical chemical properties of 2-amino-4-(trifluoromethoxy)butanoic acid – a CF3O-containing analogue of natural lipophilic amino acids

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Abstract

2-Amino-2-(trifluoromethoxy)butanoic acid (O-trifluoromethyl homoserine) was synthesized as a racemate and in both enantiomeric forms. The measured pKa and log D values establish the compound as a promising analogue of natural aliphatic amino acids.

Graphical abstract: Synthesis and physical chemical properties of 2-amino-4-(trifluoromethoxy)butanoic acid – a CF3O-containing analogue of natural lipophilic amino acids

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Publication details

The article was received on 08 Nov 2016, accepted on 06 Dec 2016 and first published on 06 Dec 2016


Article type: Paper
DOI: 10.1039/C6OB02436J
Citation: Org. Biomol. Chem., 2017,15, 672-679
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    Synthesis and physical chemical properties of 2-amino-4-(trifluoromethoxy)butanoic acid – a CF3O-containing analogue of natural lipophilic amino acids

    I. S. Kondratov, I. G. Logvinenko, N. A. Tolmachova, R. N. Morev, M. A. Kliachyna, F. Clausen, C. G. Daniliuc and G. Haufe, Org. Biomol. Chem., 2017, 15, 672
    DOI: 10.1039/C6OB02436J

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