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Issue 2, 2017
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The first total synthesis of the marine acetylenic alcohol, lembehyne B – a selective inducer of early apoptosis in leukemia cancer cells

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Abstract

The communication reports a new stereoselective method for the synthesis of a natural acetylenic alcohol, lembehyne B. The key stage of the process uses new cross-cyclomagnesiation reaction of aliphatic and oxygenated 1,2-dienes with Grignard reagents in the presence of a catalytic amount of Cp2TiCl2. A study of the cytotoxic properties of lembehyne B on tumor cell lines using flow cytometry demonstrated that this is a selective inducer of early apoptosis of the Jurkat, HL-60 and K562 cell cultures and hypodiploid (sub-G1) sub-population inducer in cell cycle studies for all cell lines used.

Graphical abstract: The first total synthesis of the marine acetylenic alcohol, lembehyne B – a selective inducer of early apoptosis in leukemia cancer cells

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Publication details

The article was received on 28 Oct 2016, accepted on 24 Nov 2016 and first published on 08 Dec 2016


Article type: Paper
DOI: 10.1039/C6OB02346K
Citation: Org. Biomol. Chem., 2017,15, 470-476
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    The first total synthesis of the marine acetylenic alcohol, lembehyne B – a selective inducer of early apoptosis in leukemia cancer cells

    L. U. Dzhemileva, V. A. D'yakonov, A. A. Makarov, E. N. Andreev, M. M. Yunusbaeva and U. M. Dzhemilev, Org. Biomol. Chem., 2017, 15, 470
    DOI: 10.1039/C6OB02346K

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