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Issue 8, 2017
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Incorporation of large guest molecules into liposomes via chemical reactions in lipid membranes

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Abstract

The incorporation of hydrophobic guest molecules into lipid membranes by the exchange of the guest molecule from a cyclodextrin (CDx) complex to a liposome is limited to guest molecules that can be included in CDxs. To solve this problem, large guest molecules were incorporated into liposomes by chemical reactions of guest molecules in lipid membranes. Stable lipid-membrane-incorporated fullerene derivatives with large substituent(s) were prepared by Diels–Alder reactions in lipid membranes.

Graphical abstract: Incorporation of large guest molecules into liposomes via chemical reactions in lipid membranes

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Publication details

The article was received on 28 Oct 2016, accepted on 25 Nov 2016 and first published on 25 Nov 2016


Article type: Paper
DOI: 10.1039/C6OB02343F
Citation: Org. Biomol. Chem., 2017,15, 1786-1791
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    Incorporation of large guest molecules into liposomes via chemical reactions in lipid membranes

    Y. Tsuchiya, K. Sugikawa, M. Ueda and A. Ikeda, Org. Biomol. Chem., 2017, 15, 1786
    DOI: 10.1039/C6OB02343F

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